| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284645 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Schisandrol A, a dibenzocyclooctadiene lignan, was obtained by a simplified procedure from Schisandra chinensis fruits. Its reaction with carboxylic acids to give new esters (schisantherins) required special conditions such as microwave irradiation. An X-ray single crystal structure analysis of schisandrol A revealed a sterical shielding of the secondary OH group as the likely reason. The cinnamoate inhibited the P-gp drug transporters of multidrug-resistant human Kb-V1 cervix carcinoma cells better than the natural benzoate and comparable to the clinical sensitizer verapamil.
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Authors
Rainer Schobert, Werner Kern, Wolfgang Milius, Tamara Ackermann, Miroslava Zoldakova,