| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284647 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A series of bicyclic pyridine containing alkaloids related to (â)-cytisine and varenicline are described. Synthetic access via regioisomeric metalation of alkoxy- and halo-pyridines gains entry to all four isomeric [3.3.1]-bicyclic targets. Regioselective and sequential oxidative cleavage of dicyclopentadiene generates a related [3.2.1]-bicyclic analog.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sebastien Demers, Heather Stevenson, John Candler, Crystal G. Bashore, Eric P. Arnold, Brian T. O'Neill, Jotham W. Coe,