| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284682 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A Biginelli-type condensation is described using dialkyl acetone-1,3-dicarboxylates as active methylene compounds for the preparation of monastrol analogues. Unexpectedly, the reaction with salicylaldehyde formed two different products depending on the ester alkyl group. This product dichotomy was found to be caused by the steric effects exerted by the alcohol terminus of the ester group in the active methylene component. Previous controversial results as to the structure of the Biginelli product 3 are also discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jan SveËtlÃk, Lucia Veizerová, Viktor Kettmann,