Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5284910 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
We disclosed a novel 'racemization-free segment condensation' based on the 'O-acyl isopeptide method' in which an N-segment including C-terminal O-acyl isopeptide structure with urethane-protected Ser/Thr residue was employed for the segment condensation, suggesting that the use of this method contributes to the effective convergent synthesis of long peptides/proteins.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Taku Yoshiya, Youhei Sohma, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso,