| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5284970 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
The kinamycins are biologically active secondary metabolites characterized by an uncommon diazobenzo[b]fluorene skeleton. Kinamycin D has been shown to potently cleave DNA under mild biomimetic conditions. Use of the endogenously abundant reductant glutathione at 570 μM, kinamycin D effectively cleaved DNA in a concentration, temperature, and time-dependent fashion. Dithiothreitol also proved effective at low concentration while other reductants failed to induce DNA cleavage. Mechanistic consequences of the DNA cleavage results are described.
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Authors
T. Eric Ballard, Christian Melander,