| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5285196 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
1-Selenocarbamoylpiperidine 2 chemoselectively cleaves the O-chloroacetyl group in the presence of other acyl groups such as acetyl, pivaloyl, and Fmoc without the assistance of a base. The high lipophilicity of 2 allowed us to use 1,4-dioxane, THF, and DMF as reaction solvents, thereby enabling dechloroacetylation at high temperature. A comparative experiment with other dechloroacetyl reagents showed that selenourea 2 has a high potential as a dechloroacetylation reagent.
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Authors
Shingo Sogabe, Hiromune Ando, Mamoru Koketsu, Hideharu Ishihara,