Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5285199 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
An efficient one-pot stereoselective synthesis of trisubstituted (E)-2-methylalk-2-enoic acids has been accomplished by treatment of unactivated Baylis-Hillman adducts, 3-hydroxy-2-methylenealkanoates, with Al-NiCl2·6H2O in methanol at room temperature followed by hydrolysis. The method has been applied to the synthesis of three important insect pheromones, (4S,2E)-2,4-dimethyl-2-hexenoic acid, (+)-(S)-manicone and (+)-(S)-normanicone.
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Authors
Biswanath Das, Nikhil Chowdhury, Joydeep Banerjee, Anjoy Majhi,