| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5285467 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Asymmetric nitroaldol reaction of α-ketoesters was explored using a guanidine-thiourea bifunctional organocatalyst at temperatures below the freezing point of water. The new reaction protocol can be applied to the nitroaldol reaction of nitroalkanes and α-ketoesters to construct the adjacent stereocenters of the chiral tertiary alcohol product with high diastereo- and enantioselectivity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Keisuke Takada, Nobuko Takemura, Kaori Cho, Yoshihiro Sohtome, Kazuo Nagasawa,