| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5285870 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
An efficient, stereoselective method for the synthesis of α-phosphonoenamines based on a modified Peterson olefination is described. The carbanion derived from isolatable intermediate 2 reacts with aromatic or aliphatic aldehydes selectively eliminating in Peterson fashion to deliver functionally rich α-phosphonoenamines 3. The synthetic utility of these enamines is demonstrated by their hydrolysis yielding the homologous carboxylic acids in good yield.
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Authors
James McNulty, Priyabrata Das, Don Gosciniak,