Article ID Journal Published Year Pages File Type
5285874 Tetrahedron Letters 2008 4 Pages PDF
Abstract
A brief and efficient synthesis of various N-arylated racemic aspartates has been achieved by two consecutive reactions in one-pot, in which imine or equivalent, formed in situ from various anilines and ethyl glyoxylate, reacted with the Reformatsky reagent, tert-butyl 2-bromozinc acetate. Notably the two esters are orthogonally protected for the convenience of further derivatization.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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