Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5285874 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A brief and efficient synthesis of various N-arylated racemic aspartates has been achieved by two consecutive reactions in one-pot, in which imine or equivalent, formed in situ from various anilines and ethyl glyoxylate, reacted with the Reformatsky reagent, tert-butyl 2-bromozinc acetate. Notably the two esters are orthogonally protected for the convenience of further derivatization.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guanglin Luo, Ling Chen, Rita Civiello, Gene M. Dubowchik,