Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5285880 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and the non-specific electrostatic interaction with the phosphate groups of DNA.
Related Topics
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Authors
Marcela Tkadlecová, Jarmila Foltýnová, Martin ValÃk, VladimÃr Král,