Article ID Journal Published Year Pages File Type
5285888 Tetrahedron Letters 2008 5 Pages PDF
Abstract
The chiral and stereoselective synthesis of (−)-dihydroisocodeine 2, the known synthetic intermediate of (−)-morphine 1, is described. The vicinal tertiary and quaternary stereocenters in 2 were effectively generated in one-step reaction based on the cascade sequential Claisen rearrangement of a cyclohexene-diol derived from d-glucal.
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Physical Sciences and Engineering Chemistry Organic Chemistry
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Formal synthesis of (−)-morphine from d-glucal based on the cascade Claisen rearrangement
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