Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5286312 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A general synthetic route for the Pd-catalyzed cross-coupling of an arylzinc reagent with arylvinyl iodides (Negishi cross-coupling) has been developed. The system permits efficient and selective preparation of E-stilbenes and their analogues. It also functions effectively at low levels of catalyst loading without the need for an additional ligand and tolerates a wide range of functional groups including heteroaromatic substrates. A systematic study of various parameters was performed and correlated with catalyst-substrate activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M. Shahjahan Kabir, Aaron Monte, James M. Cook,