An efficient, continuous flow technique for the chemoselective synthesis of thioacetals

Owing to the unique reaction conditions obtained in continuous flow packed-bed systems, we are able to overcome selectivity issues frequently encountered in traditional stirred reactor vessels, enabling the synthesis of analytically pure compounds with ease. In addition, the synthesis of numerous thioacetals and thioketals is reported, demonstrating reaction reproducibility unparalleled by traditional stirred or shaken reactor methodology.