Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5286738 | Tetrahedron Letters | 2005 | 5 Pages |
Abstract
The ability of amino acids to catalyze dynamic kinetic asymmetric transformation (DYKAT) with excellent stereoselectivity is presented. The novel DYKAT process was applied in the proline-catalyzed one-step de novo synthesis of triketide- and deoxysugars, which were formed with excellent diastereoselectivity and up to 99% ee. The de novo synthesis is accomplished via an enzyme-like DYKAT process, which includes continuous amino acid-mediated racemization of the acceptor β-hydroxy aldehyde in combination with amino acid-catalyzed direct selective aldol addition.
Related Topics
Physical Sciences and Engineering
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Authors
Efraim Reyes, Armando Córdova,