| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5287026 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A simple and efficient general approach to various quinazolinone scaffolds, including peptidomimetic examples, has been demonstrated by employing HMDS/I2 for the intramolecular dehydrative cyclization of diamides. The protecting groups -Boc, -Fmoc and -Cbz tolerated the present reaction conditions and we did not observe any racemization. The present protocol has also been used as a key step for the efficient four-step syntheses of the naturally occurring quinazolinones, sclerotigenin, (â)-circumdatin-F and (â)-fumiquinazoline-F.
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Authors
Umesh A. Kshirsagar, Santosh B. Mhaske, Narshinha P. Argade,