| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5287391 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
S.F. Vasilevsky, L.M. Gornostaev, A.A. Stepanov, E.V. Arnold, I.V. Alabugin,