The first enantiospecific total synthesis of (+)-seychellene

The first enantiospecific total synthesis of the tricyclic sesquiterpene (+)-seychellene, starting from (R)-carvone via (S)-3-methylcarvone, has been accomplished employing a combination of an intermolecular Michael addition-intramolecular Michael addition sequence and an intramolecular alkylation reaction for the generation of the two vicinal quaternary carbon atoms.

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