| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5287595 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The stereochemical preference for the cytochrome P450BM3-catalysed hydroxylation of tetradecanoic and pentadecanoic acids has been determined via comparison with authentic non-racemic standards utilising enantioselective HPLC. The sub-terminal hydroxylation of these fatty acids by P450BM3 is highly selective for the formation of the R-alcohols. This is the same enantioselectivity as is seen for hexadecanoic acid oxidation but contrasts with a previous report of S-hydroxylation of pentadecanoic acid by P450BM3.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Max J. Cryle, Nick J. Matovic, James J. De Voss,