Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5287601 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
We present a highly stereoselective procedure for the preparation of (2S and 2R,3S,4R,5S)-5-methyl-3,4-dihydroxy-2- ethoxycarbonylmethylpyrrolidines based on conjugate addition of ammonia to unsaturated aldonic esters derived from d-ribose followed by tandem cyclization. Derivatisation of these compounds to 2-hydroxyethyl-, benzymidazolylmethyl-, biphenyl-1-aminoethyl and naphthalene-l-aminoethyl-pyrrolidines is also presented.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Inmaculada Robina,