Article ID Journal Published Year Pages File Type
5287776 Tetrahedron Letters 2006 4 Pages PDF
Abstract
An efficient method for the synthesis of antitumor TMC-69-6H and related analogs which have been demonstrated to be phosphatase (PTP1B, VHR, and PP1) inhibitors, is reported. This strategy involves two key steps: a diastereoselective aldol reaction and a one-pot tandem ring-closing and cross metathesis for the construction of the pyran moiety.
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Physical Sciences and Engineering Chemistry Organic Chemistry
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New strategy for the synthesis of phosphatase inhibitors TMC-69-6H and analogs
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