Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5288551 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
An efficient, enantioselective total synthesis of (â)-lasubine I (1) has been achieved in an overall 8.8% yield from readily available starting materials. The important features of this approach include the creation of stereogenic centers through two sequential highly stereoselective Roush allylborations and the use of SN2 cyclization and ring-closing metathesis reactions for the construction of the quinolizidine skeleton.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shengyang Liu, Yuping Fan, Xinxiang Peng, Wei Wang, Weiyi Hua, Haji Akber, Lixin Liao,