| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5288653 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
A two-step procedure for the preparation of ethyl 4-amino-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (enaminone) and methyl 4-hydroxy-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (vinylogous acid) has been accomplished, using reactive Michael acceptors under basic condition. In addition, acyclic trifluoromethylated ester derivatives were isolated as competing by-products. The above compounds represent novel synthetically useful trifluoromethyl building blocks.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cosmas O. Okoro, Olugbeminiyi O. Fadeyi, Patrice L. Jackson, Rhonda L. Richmond, Takeisha Farmer,