| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5288892 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
With the aid of proposals from a computer program for synthesis design, a new method of synthesizing azaspiranes has been developed. In this method, one starts with a suitable benzoic acid ester, which is subjected to Birch reduction. Then the anionic intermediate is alkylated with 1,2-dibromoethane. The product is subsequently reacted with an amine to give a spiro lactam.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akio Tanaka, Takashi Kawai, Tetsuhiko Takabatake, Noriko Oka, Hideho Okamoto, Malcolm Bersohn,