| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5288917 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
A solid phase strategy has been developed for the synthesis of tetrahydro-β-carboline alkaloid library. The key transformation is an acid-catalyzed tandem intramolecular Pictet-Spengler cyclization from l-tryptophan, which forms acyl iminiums with synchronous cleavage of products from the acid-labile SASRIN⢠solid support. A pilot library with two diversity points has been successfully synthesized in high purity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sung-Chan Lee, Soo Young Choi, Young Keun Chung, Seung Bum Park,