| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5289280 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
A highly stereoselective synthesis of the C9-C21 fragment of debromoaplysiatoxin and oscillatoxins A and D has been devised. This new approach relies on the cross coupling of titanium enolates from N-acyl-1,3-thiazolidine-2-thiones and dialkyl acetals and the selective hydrogenolysis of O-benzyl protecting groups.
Graphical abstractStereoselective synthesis of the benzyl-protected C9-C21 fragment common to debromoaplysiatoxin and oscillatoxins A and D is disclosedDownload full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Annabel Cosp, Enric Llà cer, Pedro Romea, Fèlix UrpÃ,