| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5289606 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Simple amides and esters are conveniently deprotonated by Zn(tmp)2 (tmp = 2,2,6,6-tetramethylpiperidinyl anion) to generate Zn enolates. Enolates formed by this method are suitable for use in aldol reactions that tolerate base-sensitive functional groups. Additionally, the Zn enolates are readily coupled with aryl bromides using typical Pd-catalyzed coupling methods.
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Authors
Mark L. Hlavinka, John R. Hagadorn,