Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5289637 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8â11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li-Mei Li, Guo-You Li, Wei-Lie Xiao, Yan Zhou, Sheng-Hong Li, Sheng-Xiong Huang, Quan-Bin Han, Li-Sheng Ding, Li-Guang Lou, Han-Dong Sun,