Article ID Journal Published Year Pages File Type
5289748 Tetrahedron Letters 2006 4 Pages PDF
Abstract
We have described the first total synthesis of the natural product, (+)-8-methoxygoniodiol, and its analogue, 8-deoxygoniodiol using a catalytic asymmetric hetero-Diels-Alder/allylboration sequence involving three partners. The cytotoxic activity of these final compounds and of two synthetic intermediates has been evaluated against human cancer cell lines (A375P and A375M), showing the importance of the lactone moiety.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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