Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5289782 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Barbier type additions of allylic bromide 4, derived from (Z)-but-2-en-1,4-diol 2 to (R)-2,3-cyclohexylideneglyceraldehyde 1 were performed through mediation with Zn employing Luche's procedure and also with low valent Cu, Co, and Fe which were produced via bimetal redox strategy in THF to afford 5c,d as the major products. From these, 5a,b were prepared following an oxidation-reduction protocol. Compound 5c was exploited as a representative starting material to develop a simple and inexpensive strategy toward the synthesis of 3â²-C-branched 2â²,3â²-dideoxynucleosides having stereodiversity at 3â²- and 4â²-positions.
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Authors
Angshuman Chattopadhyay, Dibakar Goswami, Bhaskar Dhotare,