Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5290080 | Tetrahedron Letters | 2006 | 6 Pages |
Abstract
α-Hydroxyketones undergo MnO2-mediated oxidation, followed by in situ trapping with 2-pyridylamidrazone, to give 3-pyridyl-5-substituted 1,2,4-triazines in a one-pot procedure, which avoids the need to isolate the reactive α-ketoaldehyde intermediates. By modifying this procedure to allow condensation prior to oxidation, the corresponding 6-substituted 1,2,4-triazines were obtained. The preparation of a novel unsymmetrical 2,2â²-bipyridine using one of the pyridyl 1,2,4-triazines prepared herein is also described.
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Authors
Surat Laphookhieo, Stuart Jones, Steven A. Raw, Yolanda Fernández Sainz, Richard J.K. Taylor,