Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5290089 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
A highly efficient total synthesis of 7-deoxypancratistatin is described. The synthesis features the ready preparation of the phenanthridone skeleton by a Stille-IMDAF cycloaddition cascade. The resulting cycloadduct is converted into a key aldehydic intermediate, which is then induced to undergo a stereospecific decarbonylation reaction using Wilkinson's catalyst to set the trans B-C ring junction of the target molecule.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongjun Zhang, Albert Padwa,