Article ID Journal Published Year Pages File Type
5290089 Tetrahedron Letters 2006 4 Pages PDF
Abstract
A highly efficient total synthesis of 7-deoxypancratistatin is described. The synthesis features the ready preparation of the phenanthridone skeleton by a Stille-IMDAF cycloaddition cascade. The resulting cycloadduct is converted into a key aldehydic intermediate, which is then induced to undergo a stereospecific decarbonylation reaction using Wilkinson's catalyst to set the trans B-C ring junction of the target molecule.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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