Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5290309 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
N-Alkylimines derived from cyclobutanones have not been evaluated in depth as building blocks for organic synthesis, although these compounds are, among others, good precursors for interesting 3-arylcyclobutylamines. The reduction of various N-alkyl-N-(3-arylcyclobutylidene)amines with LiAlH4 yielded cis-substituted cyclobutylamines as the only stereoisomers. When borane was used as a reducing agent, an intermediate imine-borane complex could be isolated as a stable compound.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guido Verniest, Sven Claessens, Norbert De Kimpe,