Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5291153 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
We have developed the chemo- and regioselective phosphitylation of unprotected 2â²-deoxyribonucleosides by the use of di-tert-butyl N,N-diethylphosphoramidite, a sterically hindered phosphoramidite. Both N/O- and primary hydroxy group-selectivities were simultaneously achieved, and the selectivity for the 5â²-hydroxy groups was up to 97% regardless of the base moiety of the 2â²-deoxyribonucleosides. The 3â²-O-isomers and the 5â²-O-isomers were easily separated by silica gel column chromatography or crystallization to give the pure 2â²-deoxyribonucleoside 5â²-phosphites in moderate to good yields.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yukiko Kato, Natsuhisa Oka, Takeshi Wada,