Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5291582 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The biosynthetic pathway of a potent antifungal agent, FR-900848, has been examined by administration of several 13C-labeled precursors to Streptoverticillium fervens HP-891. Although none of the 13C-labeled acetate was incorporated into FR-900848, the labeling pattern of FR-900848 derived from d-[U-13C6]glucose revealed that the fatty acid backbone of FR-900848 has been biosynthesized via a polyketide pathway. These unusual results strongly show that the major pathway to provide acetyl-CoA in this microorganism is glycolysis. Feeding experiments with d-[U-13C6]glucose, [1,3-13C2]glycerol, and l-[Me-13C]methionine provided information on the biosynthetic origin of structurally unusual parts (polycyclopropane and aminonucleoside) in this antibiotic.
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Authors
Hiroaki Watanabe, Tetsuo Tokiwano, Hideaki Oikawa,