Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5291930 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
Peptidotriazoles, unnatural oligomers with alternating amide and triazole linkages, are synthesized efficiently on solid support. The key transformations involve multiple cycles of 1,2,3-triazole formation, using soluble Cu(I) catalyst and conditions that do not generate precipitate on solid support nor require exclusion of oxygen. Our synthetic protocol will enable the preparation of other unnatural oligomers with multiple triazoles using solid phase methodologies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhongsheng Zhang, Erkang Fan,