Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5292124 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The thermolysis of 1,2-dialkynylimidazoles in benzene solution affords high yields of 7-phenyl-5H-cyclopentapyrazines, which presumably form by solvent trapping of cyclopentapyrazine carbene intermediates. In cases where dialkynylimidazole contains side chains that can participate in intramolecular carbene C-H insertion or olefin addition, these processes compete with solvent addition to afford novel tri- and tetracyclic pyrazines, which can be obtained in good yield when the thermolysis is carried out in hexafluorobenzene.
Related Topics
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Authors
Asha K. Nadipuram, Sean M. Kerwin,