| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5292853 | Tetrahedron Letters | 2005 | 4 Pages |
Abstract
An effective solid-phase preparation of anilides from supported carboxylic acids is described by their activation as the corresponding acid chlorides with TMUCl Cl.
Keywords
SPPS, solid-phase peptide synthesisNP, normal phaset-Bu, tert-butylBoc, tert-butyloxycarbonylDIEA, N,N-diisopropylethylamineDMF, N,N-dimethylformamideFmoc, 9-fluorenylmethoxycarbonylHOBt, 1-hydroxybenzotriazoleMS, mass spectroscopyNMM, N-methylmorpholinep-NitroanilidePh, phenylPS, polystyreneTFA, trifluoroacetic acidAc, acetylAmide formationDCM, dichloromethanePeptide synthesisCombinatorial chemistryAll, allylCoupling reagentsHPLC, high performance liquid chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![N-[Chloro(dimethylamino)methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides](/preview/png/5292853.png "First Page Preview: N-[Chloro(dimethylamino)methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides")
Authors
Marc Vendrell, Rubén Ventura, Ariel Ewenson, Miriam Royo, Fernando Albericio,