Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5349670 | Applied Surface Science | 2014 | 29 Pages |
Abstract
Graphene oxide nanoribbons (GONRs) were synthesized using an oxidative unzipping of multi-walled carbon nanotubes. The interactions of the GONRs with various concentrations of fetal bovine serum or human plasma serum indicated that the GONRs were functionalized substantially by the albumin originated from the two different protein sources. Then, concentration-dependent cytotoxicity of the protein-functionalized GONRs on human epithelial cells was studied. Although the GONRs with concentrations â¤50 μg/mL did not exhibit significant cytotoxicity on the cells (with the cell viability >85%), the concentration of 100 μg/mL exhibited significant cytotoxicity including prevention of cell proliferation and induction of cell apoptosis. These results can provide more in-depth understanding about cytotoxic effects of graphene nanostructures which can be functionalized by the proteins of media.
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Authors
Doris A. Mbeh, Omid Akhavan, Taraneh Javanbakht, Morteza Mahmoudi, L'Hocine Yahia,