Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5349825 | Applied Surface Science | 2015 | 9 Pages |
Abstract
Despite the attractive properties of carbon nanotubes (CNTs), cytoxicity and hydrophobicity are two main considerable features which limit their application in biomedical fields. It was well established that treating CNTs with extracellular matrix components could reduce these unfavourable characteristics. In an attempt to address these issues, fibronectin (FN) with different concentrations was loaded on single walled carbon nanotubes (SWCNTs) substrate. Scanning electron microscope, atomic force microscopy (AFM), contact angles and X-ray photoelectron spectroscopy (XPS) were preformed in order to characterize FN loaded SWCNTs substrates. According to XPS and AFM results, FN could interact with SWCNTs and for this, the hydrophilicity of SWCNTs was improved. Additionally, SWCNT modified with FN showed less cytotoxicity compared with neat SWCNT. Finally, FN was shown to act as an interesting extracellular component for enhancing the biological properties of SWCNT.
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Authors
Fatemeh Mottaghitalab, Mehdi Farokhi, Fatemeh Atyabi, Ramin Omidvar, Mohammad Ali Shokrgozar, Majid Sadeghizadeh,