| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5351508 | Applied Surface Science | 2014 | 7 Pages |
Abstract
Amino-functional hollow mesoporous silica could effectively immobilize d-amino acid oxidase (DAO), and enhance stability of DAO. After going through endocytosis, cytotoxicity of the nanocapsules immobilizing DAO could be regulated by exogenous administration of d-amino acids to generate H2O2 with strong oxidbillity, which can readily cross cellular membranes and then directly cause oxidative damage to DNA, proteins and lipids.
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Authors
Yang Zhao, Yingchun Zhu, Jingke Fu,