| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5354305 | Applied Surface Science | 2013 | 7 Pages |
Abstract
Here we show by means of DPFM-AFM that Alginate Lyase (AlgL), an enzyme known to reduce negatively charged alginate levels in microbial biofilm, is able to reduce the biofilm adhesion forces forming several nano-fractures in the ECM. These results suggest that the AlgL could used to enhance the antifungal drugs transit through the ECM.
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Physical and Theoretical Chemistry
Authors
Alessandro Maiorana, Massimiliano Papi, Francesca Bugli, Riccardo Torelli, Giuseppe Maulucci, Margherita Cacaci, Brunella Posteraro, Maurizio Sanguinetti, Marco De Spirito,