| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5360924 | Applied Surface Science | 2012 | 8 Pages |
Abstract
⺠We prepared ultra-high molecular weight polyethylene (UHMWPE) loaded with 17β-estradiol (E2) to treat osteolysis after artificial joint replacement. ⺠We investigate the in vitro release of E2 and the cell biological response to UHMWPE-E2 wear debris. ⺠The in vitro E2 release included three stages during the release process: initial burst release, celerity release and steady release. ⺠The UHMWPE-E2 wear debris could promote the proliferation and ALP activity of osteoblasts and inhibit the expression of IL-6 of osteoblasts. ⺠The E2 in UHMWPE-E2 would play a role in the treatment of the osteolysis after artificial hip joint replacement.
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Authors
Shuxin Qu, Aiqin Liu, Xiaomin Liu, Yinlong Bai, Jie Weng,