Phase transfer synthesis of N,N′(1,2-phenylene)bis-hippuricamide tethered metal based functionalized nanoparticles: A study on some novel microbial targeting peptide-mimic nanoparticles

This paper presents the novel synthesis of peptide, N,N′(1,2-phenylene)bis-hippuricamide tethered metal [Cu(II), Zn(II), Ni(II) and Co(II)] based functionalized nanoparticles via modified Brust-Schiffrin methodology. The growth, organic composition and morphology of these functionalized nanoparticles have been evaluated by UV-Vis, FT-IR spectroscopy and scanning electron microscopy. They are structurally and thermally characterized by X-ray diffraction and thermogravimetric analysis. Moreover, the interfacial dealings of these functionalized nanoparticles with Calf-thymus DNA and pUC19 DNA reveal that the functionalized nanoparticles of cobalt is an effective DNA damaging agent under physiological conditions. This has been supported by its efficient antimicrobial character against few fungal and bacterial strains, thereby steering its way towards biomedical applications as a metal based nanocarrier.

Graphical abstractA new versatile peptide ligand and its four metal based functionalized nanoparticles have been synthesized via modified Brust-Schiffrin approach. The remarkable DNA binding affinity and their excellent bioactive properties against microbial strains suggest a potential application of nanoscience towards the development of novel peptide based biomarkers.Download full-size imageHighlights► Synthesis of metal based functionalized nanoparticles via modified Brust-Schiffrin approach. ► DNA interfacial dealings explored the excellent DNA damaging property of these nanoparticles. ► Biological studies clearly depict the potential value of peptide in these types of nanoparticles. ► The functionalized nanoparticle of cobalt is the most active microbial marker among the others.