| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5364502 | Applied Surface Science | 2012 | 6 Pages |
A bioavailable surface generated by nano-technology could accelerate implant osteointegration, reduce healing time and enable implants to bear early loading. In this study, a nano-porous surface of titanium wafers was modified using micro-arc oxidation technique; surface of smooth titanium was used as control group. Surface characteristic was evaluated by investigating morphology, roughness and hydrophilicity of titanium wafers. In vitro studies, osteoblastic adhesion, proliferation and ALP activity, as well as gene and protein expressions relative to mineralization were assayed. Our results showed that a crater-liked nano-porous surface with greater roughness and better hydrophilicity were fabricated by micro-arc oxidation. It was further indicated that nano-porous surface could enhance adhesion, proliferation and ALP activity of osteoblasts compared with smooth surfaces. In addition, gene and protein expression of collagen-I, osteocalcin and osteopontin were also obviously increased. In summary, micro-arc oxidized techniques could form an irregular nano-porous morphology on implant surface which is favorable to improve osteoblastic function and prospected to be a potent modification of dental implant.
⺠Micro-arc oxidation technology formed a porous feature on titanium surface. ⺠This porous surface accelerated adhesion, proliferation and differentiation compared with smooth surface. ⺠Osteogenesis-related proteins and genes were up regulated by this porous surface. ⺠It is anticipated that micro-arc oxidation surface could enhance osteoblastic activity and bone regeneration.
