Interactions of ferrimagnetic glass/glass-ceramics with bovine serum albumin

Glasses/glass-ceramics with nominal composition 34 SiO2-(45 − x)CaO-16P2O5-4.5MgO-0.5CaF2 − xFe2O3 (where x = 10, 15, 20 wt%) have been prepared by melt quenching technique. These are characterized for structural and micro structural properties by using XRD and Raman spectroscopy. Interaction of glass-ceramics samples with bovine serum albumin (BSA) has been studied using SEM and TOF-SIMS. The formation of magnetite, apatite and wollastonite phases are observed. Typical sizes of crystallites as seen from SEM measurement are 30-50 nm. The progressive addition of iron oxide to glass leads to increase in number of non-bridging oxygen, which in turn affects the response of glass-ceramics when immersed in BSA. The samples with 15 and 20 wt% Fe2O3 have shown nearly full surface coverage with BSA, while the sample with 10 wt% Fe2O3 shows poor adhesion.

► Structural and surface properties of glassy materials 34 SiO2-(45 − x) CaO-16 P2O5-4.5 MgO-0.5 CaF2-x Fe2O3 (x = 10, 15, 20 wt%) are studied. ► Iron oxide behaves as a structural modifier in the glass compositions. ► Surface properties are modified with addition of iron oxide. ► The better response in BSA was observed when iron oxide content was increased.