| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5371438 | Biophysical Chemistry | 2011 | 8 Pages |
Abstract
⺠A homology model for P2Y12 receptor was created based on a consensus approach following with molecular dynamics simulations. ⺠The mechanisms of binding for the reversible antagonists of the P2Y12 receptor are elucidated. ⺠For the agonist, the Arg256, Lys280, and Phe252 were found as “hot” residues. ⺠For the antagonists, the Lys280 and Phe252 had hydrogen bonding contacts and Ï-Ï interactions.
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Haibo Liu, Hu Ge, Yong Peng, Peigen Xiao, Jun Xu,