| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5371639 | Biophysical Chemistry | 2010 | 6 Pages |
Abstract
Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.
Related Topics
Physical Sciences and Engineering
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Physical and Theoretical Chemistry
Authors
Chang Jun Lee, Sangwook Wu, Changsun Eun, Lee G. Pedersen,