Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5371657 | Biophysical Chemistry | 2009 | 4 Pages |
Abstract
Eukaryotes have evolved complex cellular responses to double-stranded RNA. One response that is highly conserved across many species is the RNA silencing pathway. Tombusviruses have evolved a mechanism to evade the RNA silencing pathway that involves a small protein, p19, that acts as a suppressor of RNA silencing. This protein binds specifically to small-interfering RNAs (siRNAs) with nanomolar affinity in a sequence-independent manner and with size selectivity.
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Authors
Roger Koukiekolo, Zygmunt J. Jakubek, Jenny Cheng, Selena M. Sagan, John Paul Pezacki,