| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5372406 | Biophysical Chemistry | 2006 | 4 Pages |
Abstract
Magnetic force microscopy (MFM) has been employed to observe antisense oligonucleotides (ASOs)-coupled silica-coated magnetic iron oxide nanoparticles (SMNPs) internalized into human leukemia (HL-60) cells. The experiment demonstrated that the ASOs-coupled SMNPs delivery into the cells really occurred. The nanoparticles were internalized into the cells and the apoptotic topography can be directly visualized simultaneously with MFM technology. These present observations offer direct morphology evidence on studying the apoptosis of tumor cells and provide useful information for better design of new diagnostic and therapeutic tools in tumor treatment.
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Authors
He-bai Shen, De-hong Long, Long-zhang Zhu, Xing-yu Li, Ya-ming Dong, Neng-qin Jia, Hai-qing Zhou, Xi Xin, Yang Sun,